OpenProphetDB is an open research group focused on unlocking the potential of existing drugs to save patients with rare and complex diseases. We explore the following topics: constructing and integrating knowledge graph, multi-omics data, and deep learning models to understand the molecular mechanisms of human rare and complex diseases, or to predict new indications for known drugs through drug repurposing.
For more details, please visit the following open-source projects:
A Network Medicine Platform with knowledge graph and graph neural network for drug repurposing and disease mechanism.
Prophet Studio is a data labeling and annotation tool for biomedical knowledges. It is based on Label Studio.
The Quartet Project provides publicly accessible multi-omics reference materials and practical tools to enhance the reproducibility and reliability of multi-omics results. Well-characterized multiomics reference materials and quality control metrics pertinent to precision medicine study purposes can be used to measure and mitigate technical variation, enabling more accurate cross-batch and cross-omics data integration in increasingly large-scale and longitudinal studies such as the International Human Phenome Project.
